Natural products are the most structurally diverse naturally-occurring small molecules and continue to play important roles in treatment of human diseases. Organisms, including bacteria, fungi, animal, and plant, have served a great source of complex and diverse natural products. Many natural products have been utilized for human health. However, one of the challenges is the development of strains that are resistant to many of the antibiotics used in the clinic. To combat the drug resistance, it is important to discover new bioactive natural products or develop new drug derivatives via chemical or biological means. Our group focuses on development of new antibiotics. Research in our group combines biochemistry, natural product chemistry, enzymology, structural biology, and synthetic biology to investigate natural product biosynthesis and develop new bioactive molecules.

　　自然界中，天然產物是我們最好的藥物來源。許多來自於細菌、真菌以及動、植物的天然產物已被開發成抗菌、抗病毒、抗癌、降血脂等用藥。然而，許多疾病對現有的藥物產生抗藥性，迫使我們不斷的在自然界中尋找、發現新穎天然產物，或是利用化學與生物的方法改良藥效。我們的研究著重於天然產物化學，結合微生物學、生物化學、有機化學等基礎學科，配合生物資訊分析、酵素化學、結構生物學進一步了解天然產物生合成途徑、酵素作用機轉與抗性機制。並藉由體內基因操作、酵素工程、化學合成及組合生物學等手段產生新的天然產物衍生物，並期望從一系列衍生物中發掘新一代的抗生素。