Natural products are the most structurally diverse naturally-occurring small molecules and continue to play important roles in treatment of human diseases. Organisms, including bacteria, fungi, animal, and plant, have served a great source of complex and diverse natural products. Many natural products have been utilized for human health. However, one of the challenges is the development of strains that are resistant to many of the antibiotics used in the clinic. To combat the drug resistance, it is important to discover new bioactive natural products or develop new drug derivatives via chemical or biological means. Our group focuses on development of new antibiotics. Research in our group combines biochemistry, natural product chemistry, enzymology, structural biology, and synthetic biology to investigate natural product biosynthesis and develop new bioactive molecules.